Adrenocortical Carcinoma

What are adrenocortical carcinomas?

Adrenocortical carcinoma is a rare cancer that forms in the outer layer of the adrenal glands. These glands, which are near the front side of the kidneys, produce hormones such as different forms of steroids. These hormones control several body functions, including blood pressure, response to stress, and sexual development.

Adrenocortical carcinoma typically affects children younger than 4 and older than 13. These tumors, which frequently secrete hormones and may cause children to develop masculine traits and can spread to the kidneys, lungs, bones and brain. Many children often have Li-Fraumeni syndrome, an inherited condition that predisposes them to many types of cancer.

How we care for adrenocortical carcinomas

Children and adolescents with adrenocortical carcinoma are treated at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center through our Solid Tumor Center.