Cyclic Neutropenia

What is cyclic neutropenia?

Cyclic neutropenia is a rare blood disorder that causes episodes of low levels of neutrophils (a type of white blood cell) in the body. Neutrophils are vital to fighting infection by surrounding and destroying bacteria that enter the body. Symptoms of cyclic neutropenia may include fever, a feeling of poor health, as well as possible ulcers (sores) in the mouth. Children with cyclic neutropenia are vulnerable to recurrent infections.

Cyclic neutropenia may be inherited genetically or acquired by a developed mutation. Some cases are present at birth and appear to occur sporadically. Treatment options include quickly addressing associated infections and therapies aimed at stimulating the production of neutrophils.

How we care for cyclic neutropenia

Children with cyclic neutropenia are treated at Dana-Farber/Boston Children's Cancer and Blood Disorders Center through our Bone Marrow Failure and Myelodysplastic Syndrome Program, recognized as one of the nation’s best pediatric treatment and research programs for bone marrow failure and related conditions. Our patients have access to advanced diagnosis and treatments, including DNA mutation identification and ongoing clinical trials.