Stroke in Children | Types of Stroke in Children

Most pediatric strokes are ischemic or thrombotic in nature, meaning that blood has stopped flowing to an area of the brain for long enough to cause damage.

The major pediatric stroke conditions we treat include:

Neonatal stroke

Also known as stroke in newborns, neonatal stroke occurs in approximately 1 in 2,500 full-term infants and even more commonly in babies born prematurely. Sometimes strokes even occur before birth. Most often, neonatal stroke is discovered shortly after birth in babies who have seizures or who are weak and unresponsive, and confirmed through neuroimaging.

Ischemic stroke

Arterial ischemic strokes (AIS) in children are usually due to obstruction of blood flow to a region of the brain or spinal cord, which prevents oxygen from being delivered to it. AIS can be caused by blood clots that form inside an artery in the brain or spinal cord or by clots that pass through the heart, enter the general circulation, and then lodge in an artery in the brain or spinal cord. Structural abnormalities of the cerebral arteries themselves, known as cerebral arteriopathies, can also cause AIS. Examples include cerebral vasculitis, Ehlers-Danlos syndrome, and moyamoya disease.

Hemorrhagic stroke

Rather than ischemia, or obstruction of blood flow, some strokes occur due to bleeding, or hemorrhage, within the brain. This bleeding usually results from blood-vessel abnormalities, such as cavernous malformations, arteriovenous malformations, venous angioma, and aneurysm. Clotting disorders such as hemophilia, sickle cell disease, brain tumors, and congenital heart disease can also cause bleeds that lead to hemorrhagic stroke. Hemorrhagic stroke is also referred to as cerebral hemorrhage or intracranial hemorrhage.

Occasionally, children with ischemic stroke can develop hemorrhagic transformation of their initial stroke, meaning that bleeding can sometimes develop as a complication of the ischemic injury itself or the medicine used to treat it.

Non-traumatic cerebral hemorrhage

This term refers to bleeding in the brain that does not arise from trauma, but from blood vessel abnormalities or other disorders. It can lead to hemorrhagic stroke, but research indicates that about half of children with non-traumatic intracranial hemorrhage will have no lasting deficit. We provide close follow-up of these children to ensure optimum long-term outcomes.

Cerebral sinus thrombosis

This condition occurs when a blood clot forms in the brain's veins and dural sinuses, channels that return blood from the brain to the heart. It has been increasingly diagnosed in newborns and children, and can cause both ischemic stroke and hemorrhagic stroke. Previously, clinicians were reluctant to treat this condition with anticoagulants, which themselves can pose some risks, but confidence has grown in using these medications to prevent injury from the blood clot in selected newborns and children. These children are closely monitored by the Thrombosis and Anticoagulation Program at Boston Children's, which collaborates closely with the Stroke and Cerebrovascular Center.

Cortical venous thrombosis

Cortical or cerebral venous thrombosis occurs when a blood clot forms in a vein within the brain. Such clots can obstruct blood flow and increase blood pressure in the brain's venous circulation (the side of the circulation that returns blood to the heart), sometimes to the point that an ischemic stroke occurs. It is important to detect cortical venous thrombosis early and to consider treatment with anticoagulation.

Transient ischemic attack

Also known as TIAs, these are temporary deficits in neurologic function caused by a brief interruption of blood flow to part of the brain. While symptoms are short-lived and resolve on their own, TIAs can cause lasting injury to brain tissue. Our research indicates that about 10 percent of children who experience a TIA ultimately have a stroke, sometimes with little or no warning.