ABOUT THE RESEARCHER

OVERVIEW

Leonard Zon's laboratory focuses on the use of the zebrafish model for research into hematopoiesis and as a screen for oncogenic genes and proteins. Dr. Zon chose the zebrafish because the zebrafish embryo is completely clear, providing a "real-time" view of all organs and systems as they develop. In addition, the species is extremely fecund – each mother lays 200-300 eggs weekly – and thrifty – a large number of animals can be kept in a relatively small space.

Finally, zebrafish have several naturally occurring mutants that mirror human anemias. The Zon laboratory has spearheaded the successful effort to sequence the zebrafish genome; isolated and cloned a gene responsible for congenital anemia; identified a gene – cdx4 – which, in concert with hox, is pivotal in hematopoiesis; and found a chemical that increases blood stem cells and creates screens for genetic mutations affecting cell proliferation and cancer susceptibility in the zebrafish and for small molecule suppressors of the cancer-susceptible crb cell cycle mutant.

BACKGROUND

Leonard Zon received his MD degree from Thomas Jefferson University. He completed an internship and residency at New England Deaconess Hospital and a fellowship at Dana-Farber Cancer Institute. Dr. Zon is a Howard Hughes Medical Institute Investigator.

PUBLICATIONS

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  1. Dissecting melanocytes to predict melanoma. Nat Cell Biol. 2021 Sep; 23(9):930-931. View abstract
  2. In memory of Paul Sylvain Frenette, a pioneering explorer of the hematopoietic stem cell niche who left far too early. Exp Hematol. 2021 Aug 14. View abstract
  3. Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis. Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32). View abstract
  4. Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss. Oncogene. 2021 Jul 30. View abstract
  5. Nucleotide stress responses in neural crest cell fate and melanoma. Cell Cycle. 2021 Aug; 20(15):1455-1467. View abstract
  6. Single-cell ATAC-seq reveals GATA2-dependent priming defect in myeloid and a maturation bottleneck in lymphoid lineages. Blood Adv. 2021 07 13; 5(13):2673-2686. View abstract
  7. NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism. Cell. 2021 Aug 05; 184(16):4268-4283.e20. View abstract
  8. Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials. Nat Rev Drug Discov. 2021 08; 20(8):611-628. View abstract
  9. From development toward therapeutics, a collaborative effort on blood progenitors. Stem Cell Reports. 2021 Jul 13; 16(7):1674-1685. View abstract
  10. A phase II trial of all-trans retinoic acid (ATRA) in advanced adenoid cystic carcinoma. Oral Oncol. 2021 Aug; 119:105366. View abstract
  11. Mitochondrial function in development and disease. Dis Model Mech. 2021 Jun 01; 14(6). View abstract
  12. Cell-specific transcriptional control of mitochondrial metabolism by TIF1? drives erythropoiesis. Science. 2021 05 14; 372(6543):716-721. View abstract
  13. 'Enhancing' red cell fate through epigenetic mechanisms. Curr Opin Hematol. 2021 05 01; 28(3):129-137. View abstract
  14. Identification of Basp1 as a novel angiogenesis-regulating gene by multi-model system studies. FASEB J. 2021 05; 35(5):e21404. View abstract
  15. A uniform format for manuscript submission. Cell. 2021 Apr 01; 184(7):1654-1656. View abstract
  16. SPRED1 deletion confers resistance to MAPK inhibition in melanoma. J Exp Med. 2021 03 01; 218(3). View abstract
  17. Melanoma models for the next generation of therapies. Cancer Cell. 2021 May 10; 39(5):610-631. View abstract
  18. SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. Elife. 2021 Feb 02; 10. View abstract
  19. Blood in the water: recent uses of zebrafish to study myeloid biology. Curr Opin Hematol. 2021 01; 28(1):43-49. View abstract
  20. Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits. Nat Genet. 2020 12; 52(12):1333-1345. View abstract
  21. Recurrent co-alteration of HDGF and SETDB1 on chromosome 1q drives cutaneous melanoma progression and poor prognosis. Pigment Cell Melanoma Res. 2021 05; 34(3):641-647. View abstract
  22. Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia. Sci Transl Med. 2020 10 21; 12(566). View abstract
  23. Impact of COVID-19 Pandemic on Cancer Research. Cancer Cell. 2020 11 09; 38(5):591-593. View abstract
  24. CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23626-23635. View abstract
  25. Cross-species analysis of enhancer logic using deep learning. Genome Res. 2020 12; 30(12):1815-1834. View abstract
  26. A Transgenic System for Rapid Magnetic Enrichment of Rare Embryonic Cells. Zebrafish. 2020 10; 17(5):354-357. View abstract
  27. An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells. Blood. 2020 07 16; 136(3):269-278. View abstract
  28. PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation. Dev Cell. 2020 08 10; 54(3):317-332.e9. View abstract
  29. Long-Range Optogenetic Control of Axon Guidance Overcomes Developmental Boundaries and Defects. Dev Cell. 2020 06 08; 53(5):577-588.e7. View abstract
  30. Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma. Nat Commun. 2020 06 01; 11(1):2718. View abstract
  31. Transcriptome Dynamics of Hematopoietic Stem Cell Formation Revealed Using a Combinatorial Runx1 and Ly6a Reporter System. Stem Cell Reports. 2020 05 12; 14(5):956-971. View abstract
  32. Gain-of-Function Genetic Alterations of G9a Drive Oncogenesis. Cancer Discov. 2020 07; 10(7):980-997. View abstract
  33. Difference in biophysical properties of cancer-initiating cells in melanoma mutated zebrafish. J Mech Behav Biomed Mater. 2020 07; 107:103746. View abstract
  34. Zebrafish patient avatars in cancer biology and precision cancer therapy. Nat Rev Cancer. 2020 05; 20(5):263-273. View abstract
  35. RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells. Nat Cell Biol. 2020 04; 22(4):372-379. View abstract
  36. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020 01; 577(7792):676-681. View abstract
  37. From blood development to disease: a paradigm for clinical translation. Dis Model Mech. 2020 01 09; 13(1). View abstract
  38. The Paf1 complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors. Development. 2019 12 16; 146(24). View abstract
  39. Use of Zebrafish in Drug Discovery Toxicology. Chem Res Toxicol. 2020 01 21; 33(1):95-118. View abstract
  40. Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination. Nat Immunol. 2019 11; 20(11):1481-1493. View abstract
  41. Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment. J Exp Clin Cancer Res. 2019 Sep 13; 38(1):405. View abstract
  42. Tumor-Derived Extracellular Vesicles Breach the Intact Blood-Brain Barrier via Transcytosis. ACS Nano. 2019 12 24; 13(12):13853-13865. View abstract
  43. Author Correction: Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Nature. 2019 Sep; 573(7772):E1. View abstract
  44. Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1. Immunity. 2019 07 16; 51(1):50-63.e5. View abstract
  45. Modeling Cancer with Flies and Fish. Dev Cell. 2019 05 06; 49(3):317-324. View abstract
  46. AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate. Science. 2019 03 08; 363(6431):1085-1088. View abstract
  47. Improving the visibility of developmental biology: time for induction and specification. Development. 2019 01 16; 146(2). View abstract
  48. Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. Gastroenterology. 2019 05; 156(6):1788-1804.e13. View abstract
  49. Nfe2 is dispensable for early but required for adult thrombocyte formation and function in zebrafish. Blood Adv. 2018 12 11; 2(23):3418-3427. View abstract
  50. Stem cell safe harbor: the hematopoietic stem cell niche in zebrafish. Blood Adv. 2018 11 13; 2(21):3063-3069. View abstract
  51. Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies. Dis Model Mech. 2018 11 05; 11(11). View abstract
  52. Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma. Science. 2018 11 30; 362(6418):1055-1060. View abstract
  53. FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. J Biol Chem. 2018 12 21; 293(51):19797-19811. View abstract
  54. Stu Orkin is a superhero. J Clin Invest. 2018 10 01; 128(10):4213-4217. View abstract
  55. Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma. J Exp Med. 2018 10 01; 215(10):2673-2685. View abstract
  56. Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132. Proc Natl Acad Sci U S A. 2018 09 11; 115(37):9252-9257. View abstract
  57. Making HSCs in vitro: don't forget the hemogenic endothelium. Blood. 2018 09 27; 132(13):1372-1378. View abstract
  58. JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. J Exp Med. 2018 07 02; 215(7):1929-1945. View abstract
  59. Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche. Nature. 2018 06; 558(7710):445-448. View abstract
  60. Neural crest state activation in NRAS driven melanoma, but not in NRAS-driven melanocyte expansion. Dev Biol. 2019 05 15; 449(2):107-114. View abstract
  61. NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells. Nat Commun. 2018 05 08; 9(1):1828. View abstract
  62. Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma. Cancer Cell. 2018 04 09; 33(4):785. View abstract
  63. RNA helicase, DDX27 regulates skeletal muscle growth and regeneration by modulation of translational processes. PLoS Genet. 2018 03; 14(3):e1007226. View abstract
  64. Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma. Cancer Cell. 2018 02 12; 33(2):322-336.e8. View abstract
  65. The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spi1 expression. Biochim Biophys Acta Gene Regul Mech. 2018 Feb; 1861(2):106-116. View abstract
  66. Purification of zebrafish erythrocytes as a means of identifying a novel regulator of haematopoiesis. Br J Haematol. 2018 02; 180(3):420-431. View abstract
  67. Cancer immunotherapy: The dark side of PD-1 receptor inhibition. Nature. 2017 12 07; 552(7683):41-42. View abstract
  68. PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes. Sci Transl Med. 2017 Nov 15; 9(416). View abstract
  69. Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling. Elife. 2017 11 09; 6. View abstract
  70. Loci associated with skin pigmentation identified in African populations. Science. 2017 11 17; 358(6365). View abstract
  71. KIT Suppresses BRAFV600E-Mutant Melanoma by Attenuating Oncogenic RAS/MAPK Signaling. Cancer Res. 2017 11 01; 77(21):5820-5830. View abstract
  72. Fishing for answers in precision cancer medicine. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):10306-10308. View abstract
  73. A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development. Elife. 2017 08 23; 6. View abstract
  74. Efforts to enhance blood stem cell engraftment: Recent insights from zebrafish hematopoiesis. J Exp Med. 2017 Oct 02; 214(10):2817-2827. View abstract
  75. PGE2 pulsing of murine bone marrow cells reduces migration of daughter monocytes/macrophages in vitro and in vivo. Exp Hematol. 2017 12; 56:64-68. View abstract
  76. Blood on the tracks: hematopoietic stem cell-endothelial cell interactions in homing and engraftment. J Mol Med (Berl). 2017 08; 95(8):809-819. View abstract
  77. Identification of Padi2 as a novel angiogenesis-regulating gene by genome association studies in mice. PLoS Genet. 2017 Jun; 13(6):e1006848. View abstract
  78. From fish bowl to bedside: The power of zebrafish to unravel melanoma pathogenesis and discover new therapeutics. Pigment Cell Melanoma Res. 2017 07; 30(4):402-412. View abstract
  79. Using Zebrafish to Study Pathways that Regulate Hematopoietic Stem Cell Self-Renewal and Migration. Stem Cell Reports. 2017 06 06; 8(6):1465-1471. View abstract
  80. Efficient Transduction of Zebrafish Melanoma Cell Lines and Embryos Using Lentiviral Vectors. Zebrafish. 2017 08; 14(4):379-382. View abstract
  81. Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization. Stem Cell Reports. 2017 05 09; 8(5):1226-1241. View abstract
  82. Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes. Elife. 2017 04 07; 6. View abstract
  83. CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment. J Exp Med. 2017 04 03; 214(4):1011-1027. View abstract
  84. Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors. Sci Transl Med. 2017 02 08; 9(376). View abstract
  85. EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay. J Exp Med. 2017 03 06; 214(3):623-637. View abstract
  86. Corrigendum: Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development. Nat Cell Biol. 2017 01 31; 19(2):142. View abstract
  87. Sorting zebrafish thrombocyte lineage cells with a Cd41 monoclonal antibody enriches hematopoietic stem cell activity. Blood. 2017 03 09; 129(10):1394-1397. View abstract
  88. Chemical screening in zebrafish for novel biological and therapeutic discovery. Methods Cell Biol. 2017; 138:651-679. View abstract
  89. Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. Am J Hum Genet. 2017 Jan 05; 100(1):51-63. View abstract
  90. Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development. Nat Cell Biol. 2017 Jan; 19(1):17-27. View abstract
  91. Aging Hematopoietic Stem Cells Make Their History. Dev Cell. 2016 11 21; 39(4):390-391. View abstract
  92. Development: For cloche the Bell Tolls. Curr Biol. 2016 10 10; 26(19):R890-R892. View abstract
  93. Understanding the regulation of vertebrate hematopoiesis and blood disorders - big lessons from a small fish. FEBS Lett. 2016 Nov; 590(22):4016-4033. View abstract
  94. Transplantation in zebrafish. Methods Cell Biol. 2017; 138:629-647. View abstract
  95. MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis. Cell Stem Cell. 2016 12 01; 19(6):784-799. View abstract
  96. Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes. Blood. 2016 10 13; 128(15):1928-1939. View abstract
  97. Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease. Sci Transl Med. 2016 07 13; 8(347):347ra93. View abstract
  98. CAT7 and cat7l Long Non-coding RNAs Tune Polycomb Repressive Complex 1 Function during Human and Zebrafish Development. J Biol Chem. 2016 09 09; 291(37):19558-72. View abstract
  99. Chromatin immunoprecipitation and an open chromatin assay in zebrafish erythrocytes. Methods Cell Biol. 2016; 135:387-412. View abstract
  100. c-myb hyperactivity leads to myeloid and lymphoid malignancies in zebrafish. Leukemia. 2017 01; 31(1):222-233. View abstract
  101. Generation of Parabiotic Zebrafish Embryos by Surgical Fusion of Developing Blastulae. J Vis Exp. 2016 06 11; (112). View abstract
  102. Engineering Hematopoietic Stem Cells: Lessons from Development. Cell Stem Cell. 2016 06 02; 18(6):707-720. View abstract
  103. Modeling human diseases: an education in interactions and interdisciplinary approaches. Dis Model Mech. 2016 06 01; 9(6):597-600. View abstract
  104. Long-term drug administration in the adult zebrafish using oral gavage for cancer preclinical studies. Dis Model Mech. 2016 07 01; 9(7):811-20. View abstract
  105. Ex vivo tools for the clonal analysis of zebrafish hematopoiesis. Nat Protoc. 2016 May; 11(5):1007-20. View abstract
  106. Tissue-specific gene targeting using CRISPR/Cas9. Methods Cell Biol. 2016; 135:189-202. View abstract
  107. Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. Mol Cell. 2016 Apr 07; 62(1):34-46. View abstract
  108. Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4434-9. View abstract
  109. A Tribute to George Stamatoyannopoulos. Hum Gene Ther. 2016 Apr; 27(4):280-6. View abstract
  110. Fish to Learn: Insights into Blood Development and Blood Disorders from Zebrafish Hematopoiesis. Hum Gene Ther. 2016 Apr; 27(4):287-94. View abstract
  111. Embryonic cell culture in zebrafish. Methods Cell Biol. 2016; 133:1-10. View abstract
  112. The Red Light District and Its Effects on Zebrafish Reproduction. Zebrafish. 2016 06; 13(3):226-9. View abstract
  113. GATA Factor-G-Protein-Coupled Receptor Circuit Suppresses Hematopoiesis. Stem Cell Reports. 2016 Mar 08; 6(3):368-82. View abstract
  114. A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science. 2016 Jan 29; 351(6272):aad2197. View abstract
  115. Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis. Dev Cell. 2016 Jan 11; 36(1):9-23. View abstract
  116. Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish. Adv Exp Med Biol. 2016; 916:103-24. View abstract
  117. Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells. Cell Stem Cell. 2016 Jan 07; 18(1):73-78. View abstract
  118. Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression. Blood. 2015 Dec 24; 126(26):2811-20. View abstract
  119. Generating and evaluating a ranked candidate gene list for potential vertebrate heart field regulators. Genom Data. 2015 Dec; 6:199-201. View abstract
  120. Chamber identity programs drive early functional partitioning of the heart. Nat Commun. 2015 Aug 26; 6:8146. View abstract
  121. A Quantitative System for Studying Metastasis Using Transparent Zebrafish. Cancer Res. 2015 10 15; 75(20):4272-4282. View abstract
  122. Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol. 2015 Aug; 17(8):994-1003. View abstract
  123. Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Nature. 2015 Jul 23; 523(7561):468-71. View abstract
  124. Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction. Cell Res. 2015 Aug; 25(8):946-62. View abstract
  125. TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis. PLoS Genet. 2015 Jul; 11(7):e1005346. View abstract
  126. A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative disease. Leukemia. 2015 Dec; 29(12):2355-65. View abstract
  127. Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence. J Exp Med. 2015 May 04; 212(5):633-48. View abstract
  128. Adenosine signaling promotes hematopoietic stem and progenitor cell emergence. J Exp Med. 2015 May 04; 212(5):649-63. View abstract
  129. Screening for melanoma resistance genes in vivo. Pigment Cell Melanoma Res. 2015 Jul; 28(4):375-6. View abstract
  130. A CRISPR/Cas9 vector system for tissue-specific gene disruption in zebrafish. Dev Cell. 2015 Mar 23; 32(6):756-64. View abstract
  131. Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling. Elife. 2015 Feb 25; 4. View abstract
  132. DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish. J Hematol Oncol. 2015 Feb 22; 8:15. View abstract
  133. Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche. Cell. 2015 Jan 15; 160(1-2):241-52. View abstract
  134. Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium. Blood. 2015 Feb 26; 125(9):1418-26. View abstract
  135. A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing. Mol Cell Biol. 2015 Mar; 35(5):789-804. View abstract
  136. A comparison of non-integrating reprogramming methods. Nat Biotechnol. 2015 Jan; 33(1):58-63. View abstract
  137. Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4). Nucleic Acids Res. 2014 Oct; 42(18):11777-91. View abstract
  138. Getting more for your marrow: boosting hematopoietic stem cell numbers with PGE2. Exp Cell Res. 2014 Dec 10; 329(2):220-6. View abstract
  139. Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size. Endocrinology. 2014 Oct; 155(10):4069-80. View abstract
  140. From fish tank to bedside in cancer therapy: an interview with Leonard Zon. Dis Model Mech. 2014 Jul; 7(7):735-8. View abstract
  141. Dissection of vertebrate hematopoiesis using zebrafish thrombopoietin. Blood. 2014 Jul 10; 124(2):220-8. View abstract
  142. Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multicase Diamond-Blackfan anemia families. Blood. 2014 Jul 03; 124(1):24-32. View abstract
  143. Neural crest development and craniofacial morphogenesis is coordinated by nitric oxide and histone acetylation. Chem Biol. 2014 Apr 24; 21(4):488-501. View abstract
  144. Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures. Am J Hum Genet. 2014 Apr 03; 94(4):547-58. View abstract
  145. Unexpectedly uneven: posttransplant skeletal distribution of hematopoietic stem cell clones. J Exp Med. 2014 Mar 10; 211(3):384-5. View abstract
  146. Translational research: the path for bringing discovery to patients. Cell Stem Cell. 2014 Feb 06; 14(2):146-8. View abstract
  147. Tissue specific roles for the ribosome biogenesis factor Wdr43 in zebrafish development. PLoS Genet. 2014 Jan; 10(1):e1004074. View abstract
  148. Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish. Development. 2014 Jan; 141(1):224-35. View abstract
  149. A non-canonical function of telomerase RNA in the regulation of developmental myelopoiesis in zebrafish. Nat Commun. 2014; 5:3228. View abstract
  150. Of fish and men: using zebrafish to fight human diseases. Trends Cell Biol. 2013 Dec; 23(12):584-6. View abstract
  151. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nat Cell Biol. 2013 Dec; 15(12):1516-25. View abstract
  152. A zebrafish embryo culture system defines factors that promote vertebrate myogenesis across species. Cell. 2013 Nov 07; 155(4):909-921. View abstract
  153. A Cdx4-Sall4 regulatory module controls the transition from mesoderm formation to embryonic hematopoiesis. Stem Cell Reports. 2013; 1(5):425-36. View abstract
  154. zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish. Development. 2013 Dec; 140(24):4988-97. View abstract
  155. The zebrafish granulocyte colony-stimulating factors (Gcsfs): 2 paralogous cytokines and their roles in hematopoietic development and maintenance. Blood. 2013 Dec 05; 122(24):3918-28. View abstract
  156. Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors. Cell Stem Cell. 2013 Oct 03; 13(4):459-70. View abstract
  157. Zebrafish cancer: the state of the art and the path forward. Nat Rev Cancer. 2013 Sep; 13(9):624-36. View abstract
  158. Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation. Blood. 2013 Oct 24; 122(17):3074-81. View abstract
  159. Assaying hematopoiesis using zebrafish. Blood Cells Mol Dis. 2013 Dec; 51(4):271-6. View abstract
  160. Site-directed zebrafish transgenesis into single landing sites with the phiC31 integrase system. Dev Dyn. 2013 Aug; 242(8):949-963. View abstract
  161. Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis. Development. 2013 Jul; 140(14):3040-50. View abstract
  162. Hematopoiesis. Development. 2013 Jun; 140(12):2463-7. View abstract
  163. The histone methyltransferase SUV39H1 suppresses embryonal rhabdomyosarcoma formation in zebrafish. PLoS One. 2013; 8(5):e64969. View abstract
  164. A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development. Development. 2013 Jun; 140(11):2354-64. View abstract
  165. The zebrafish reference genome sequence and its relationship to the human genome. Nature. 2013 Apr 25; 496(7446):498-503. View abstract
  166. A model for primary melanoma of the CNS implicates NRAS. Cancer Discov. 2013 Apr; 3(4):382-3. View abstract
  167. Ageing: Stem cells on a stress-busting diet. Nature. 2013 Feb 21; 494(7437):317-8. View abstract
  168. The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models. Genome Biol. 2013; 14(10):R113. View abstract
  169. Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition. Proc Natl Acad Sci U S A. 2013 Jan 08; 110(2):E141-50. View abstract
  170. Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish. Dev Biol. 2013 Feb 01; 374(1):24-31. View abstract
  171. TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. Dev Biol. 2013 Jan 15; 373(2):422-30. View abstract
  172. The transcriptional landscape of hematopoietic stem cell ontogeny. Cell Stem Cell. 2012 Nov 02; 11(5):701-14. View abstract
  173. CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development. Nat Genet. 2012 Nov; 44(11):1260-4. View abstract
  174. Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell. 2012 Sep 14; 150(6):1135-46. View abstract
  175. Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53. PLoS Genet. 2012; 8(8):e1002922. View abstract
  176. Formation of a PKC?/ß-catenin complex in endothelial cells promotes angiopoietin-1-induced collective directional migration and angiogenic sprouting. Blood. 2012 Oct 18; 120(16):3371-81. View abstract
  177. Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis. Dev Biol. 2013 Jan 15; 373(2):431-41. View abstract
  178. A splice site mutation in laminin-a2 results in a severe muscular dystrophy and growth abnormalities in zebrafish. PLoS One. 2012; 7(8):e43794. View abstract
  179. Cancer and inflammation: an aspirin a day keeps the cancer at bay. Curr Biol. 2012 Jul 10; 22(13):R522-5. View abstract
  180. Hooked! Modeling human disease in zebrafish. J Clin Invest. 2012 Jul; 122(7):2337-43. View abstract
  181. Histocompatibility and hematopoietic transplantation in the zebrafish. Adv Hematol. 2012; 2012:282318. View abstract
  182. A great match. Cell Stem Cell. 2012 Jun 14; 10(6):638-639. View abstract
  183. In situ hybridization assay-based small molecule screening in zebrafish. Curr Protoc Chem Biol. 2012 Jun 01; 4(2). View abstract
  184. Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR. Dev Biol. 2012 Jun 15; 366(2):185-94. View abstract
  185. Nanog-like regulates endoderm formation through the Mxtx2-Nodal pathway. Dev Cell. 2012 Mar 13; 22(3):625-38. View abstract
  186. Small molecule screening in zebrafish: swimming in potential drug therapies. Wiley Interdiscip Rev Dev Biol. 2012 May-Jun; 1(3):459-68. View abstract
  187. Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell. 2012 Feb 10; 45(3):330-43. View abstract
  188. Linking hematopoietic regeneration to developmental signaling pathways: a story of BMP and Wnt. . 2012 Feb 01; 11(3):424-5. View abstract
  189. Stem cells: The right neighbour. Nature. 2012 Jan 25; 481(7382):453-5. View abstract
  190. Hematopoietic stem cells, hematopoiesis and disease: lessons from the zebrafish model. Genome Med. 2011 Dec 29; 3(12):83. View abstract
  191. Extensive genetic diversity and substructuring among zebrafish strains revealed through copy number variant analysis. Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2):529-34. View abstract
  192. An optical platform for cell tracking in adult zebrafish. Cytometry A. 2012 Feb; 81(2):176-82. View abstract
  193. Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation. Exp Hematol. 2012 Mar; 40(3):228-237.e5. View abstract
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