Venous Malformation | Research & Clinical Trials

Boston Children's Hospital is a world leader in opening new avenues of "translational research," bringing laboratory advances to the bedside and doctor's office as quickly as possible. Our Vascular Anomalies Center (VAC) conducts research that may lead to the development of new, more effective therapies and perhaps ultimately result in ways to prevent these anomalies.

Battling venous malformations at their source

A venous malformation (VM) is caused by errors that occur when blood vessels are forming, and our investigators are currently probing the genes and molecules that regulate the formation and growth of blood vessels. Understanding the genes that control these molecular events will hopefully result in new therapies for vascular malformations.

New treatment for venous malformations?

VMs can sometimes grow, requiring aggressive treatment to protect your child's health. Research at Boston Children's has shown that urine testing can help monitor VMs and predict those about to become a serious threat.

These findings suggest that angiogenesis (the formation of new blood vessels) plays a role in the progression of vascular malformations, raising the possibility of curbing these difficult-to-treat anomalies with anti-angiogenic drugs.

We’re currently studying why VMs enlarge or return after treatment. Currently no medication is available to treat venous malformations, but our goal is to develop drug treatments for kids with these lesions. Each time we operate on a VM, we investigate a portion of the lesion to learn how the blood vessels enlarge.